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Understanding Chemiluminescence Immunoassay (CLIA) in Modern Diagnostics
Chemiluminescence Immunoassay (CLIA) is a highly sensitive laboratory technique widely used in clinical diagnostics to detect and quantify biological molecules such as hormones, proteins, antibodies, and antigens. By combining the specificity of immunological reactions with the sensitivity of chemiluminescent detection, CLIA has become a cornerstone technology in modern medical laboratories.
At its core, CLIA is based on the principle of antigen–antibody binding. In this process, a target analyte in a patient sample binds to a specific antibody. What distinguishes CLIA from other immunoassays is the use of a chemiluminescent label. This label emits light as a result of a chemical reaction, and the intensity of the emitted light is directly proportional to the concentration of the target substance in the sample.
One of the major advantages of CLIA is its exceptional sensitivity. Even very low concentrations of analytes can be detected accurately, making…